Polish Society for Histamine Research
PTBH is a research organization specializing in histamine, histamine receptors, and biogenic amines in physiology, pathophysiology, and translational medicine.
JOINT CONFERENCE
Łódź · 22–24 October 2026
We invite you cordially to
Biogenic Amines and Related Biologically Active Compounds
with Histamine as a Key Amine
JOINT CONFERENCE
of the Polish Society for Histamine Research
and the Histamine Research Society Europe
Celebrating 55 years of the European Histamine Society tradition and 40 years of the Polish Society for Histamine Research.
55Years
of the European Histamine Society
52nd
European Histaminologists Meeting
40Years
of the Polish Society for Histamine Research
20th
Biennial PTBH Conference
Conference programme
Thursday, 22 October 2026
| Time | Programme |
|---|---|
| 12:00 | WELCOME Wiesława Agnieszka Fogel and Holger Stark |
| 12:15–13:15 | Session Ia. Histamine sister – Dopamine |
| 12:15 | Pertti Panula: DEVELOPMENTAL ROLES of DOPAMINE in EARLY BRAIN and in BRAIN REGENERATION |
| 12:45 | Magdalena Kurnik-Łucka: DOPAMINE in the GUT |
| 13:15–14:15 | LUNCHTIME Lunch served in hotel restaurant |
| 14:15–15:45 | Session Ib. Histamine sister – Serotonin Chairs: Jerzy Jochem & Barbara Radomanska |
| 14:15 | Philippe De Deurwaerdere: THE PSYCHEDELIC 5-METHOXY-DIMETHYLTRYPTAMINE (5-MeO-DMT) COUNTERACTS BEHAVIORAL CONSEQUENCES OF CHRONIC RESTRAINED STRESS WHILE INDUCING DISTINCT BRAIN ORGANIZATION OF NEUROTRANSMISSION SYSTEMS |
| 14:45 | Andrzej Pilc: EFFECTS OF PSYCHODELIC DRUGS SUCH AS PSILOCYBIN ARE ENHANCED BY mGlu2/3 GLUTAMATE RECEPTOR ANTAGONISTS, IMPROVING THERAPEUTIC EFFECTIVENESS AND REDUCING ADVERSE EFFECTS |
| 15:05 | Jadwiga Handzlik: MULTITARGET ACTION OF 1,3,5-TRIAZINE 5-HT6 RECEPTOR AGENTS IN SEARCH FOR NEW THERAPIES OF ALZHEIMER’S DISEASE |
| 15:30–16:10 | POSTER SESSION – ORAL PART Chairs: Bernhard Gibbs & Katarzyna Szczepanska |
| 15:30 | Dorota Łażewska: THE SEARCH FOR MAO B INHIBITORS AMONG THIOHYDANTOIN DERIVATIVES |
| 15:34 | Aleksander Gądek: INTERACTIONS BETWEEN THE HISTAMINERGIC AND OREXINERGIC SYSTEMS IN THE CENTRAL CARDIOVASCULAR REGULATION IN HAEMORRHAGIC HYPOTENSION IN RATS |
| 15:38 | Nermin Eissa: Dual Cholinesterase Inhibition and Histamine H3 Receptor Antagonism Improve Cognition and Reduce Apoptosis in a Mouse Model of Scopolamine-Induced Amnesia |
| 15:42 | Magdalena Maciuszek: SEX-DEPENDENT DIFFERENCES IN NEUROPATHIC PAIN: INSIGHTS FROM FUNCTIONAL METABOLIC PHENOTYPING AND IMMUNOLOGICAL ALTERATIONS (poster) |
| 15:46 | Marek Staszewski: COMBINING OF THE HISTAMINE H3 RECEPTOR ANTAGONIST ADS1017 WITH ARYLPIPERAZINE FRAGMENTS, TYPICAL FOR 5-HT RECEPTOR LIGANDS |
| 15:50 | Aleksandra Živkovic: RATIONAL DESIGN OF MULTITARGET-DIRECTED LIGANDS TARGETING THE HISTAMINE H3 RECEPTOR AND FERROPTOSIS PATHWAYS |
| 15:54 | Elias Böttger: METABOLIC EVALUATION OF HISTAMINE H3 RECEPTOR ANTAGONISTS IN HUMAN LIVER MICROSOME INCUBATIONS |
| 15:58 | Weronika Gonciarz: MECHANISTIC INSIGHTS INTO THE ACTION OF HISTAMINE-FUNCTIONALIZED PLA NANOPARTICLES LOADED WITH 5-FLUOROURACIL AGAINST GASTRIC CANCER CELLS IN VITRO |
| 16:10–16:30 | COFFEE BREAK |
| 16:30–17:00 | GB WEST Lecture Chairs: Madeleine Ennis |
| 16:30 | M. Beatrice Passani: THE DIVERSE ROLES OF HISTAMINE IN MODULATING COGNITIVE FUNCTIONS AND MAINTAINING INTERNAL BALANCE |
| 17:00–18:50 | Session II. Histamine, a key amine Chairs: Pertti Panula & W Agnieszka Fogel |
| 17:00 | Dariusz Szukiewicz: How the Brain's Histamine System Influences Neurodevelopmental and Neurodegenerative Disorders |
| 17:30 | Tommas Ellender: Prenatal histamine deficiency and the development of neuronal circuits |
| 17:50 | Ricardo Marquez Gomez: THE OVBNST: A NOVEL HISTAMINERGIC SOURCE MODULATING CORTICOSTRIATAL SYNAPTIC TRANSMISSION DURING EARLY POSTNATAL DEVELOPMENT |
| 18:10 | Olga Sergeeva: DIVERSITY OF MOUSE HISTAMINERGIC SYSTEM IN ADRENOCEPTOR EXPRESSION AND FUNCTION |
| 18:30 | Gustavo Provensi: HISTAMINERGIC ALTERATIONS IN PRECLINICAL MODELS OF ANOREXIA NERVOSA AND BINGE EATING DISORDER: TWO SIDES OF THE SAME COIN? |
| 18:50 | David Roeltgen: PARADOXICAL KINESIA, EMERGENCY STRENGTH, AND DRAMATIC CLINICAL BEHAVIORS, POTENTIAL ROLE OF BRAIN HISTAMINE FROM THE TUBEROMAMMILLARY NUCLEUS |
| 20:00 | DINNER Dinner at the venue restaurant |
Friday, 23 October 2026
| Time | Programme |
|---|---|
| 09:00–11:30 | Session III. Histamine & immunology Chairs: Detlef Neumann & Jaroslaw Dastych |
| 09:00 | Xavier Ligneau: BP1.7881A, THE FIRST DUAL HISTAMINE H1–H4 RECEPTOR ANTAGONIST: FROM PRECLINIC TO CLINICAL PHASE 2 STUDIES |
| 09:30 | Henry F. Vischer: Enlightning H4R pharmacology using a fluorescence-based conformational biosensor |
| 10:00 | Bernhard F. Gibbs: IgE-Dependent Histamine release from Human Basophils is inversely associated with production of the anti-inflammatory lipid mediator Resolvin-D1 |
| 10:20 | Satoshi Tanaka: FUNCTIONAL ROLES OF MAS-RELATED G PROTEIN-COUPLED RECEPTOR FAMILY IN SCRATCHING |
| 10:50 | Joao P.S. Fernandes: DISCOVERY OF CLOCINIZINE AND ANALOGUES AS POTENT ANTHELMINTIC AGENTS AGAINST NEMATODES IN VITRO AND IN VIVO |
| 11:10 | Marcin Ratajewski: SAPHYLOCOCCUS AUREUS α-HEMOLYSIN REPROGRAMS DNA METHYLATION IN HUMAN TH1 CELLS |
| 11:30–11:50 | COFFEE BREAK |
| 11:50–13:00 | Session IV. Histamine H3R Antagonists Chairs: Holger Stark & Jadwiga Handzlik |
| 11:50 | Nicholas I. Carruthers: HISTAMINE H3R ANTAGONISTS – PAST AND FUTURE |
| 12:20 | Bassem Sadek: COMBINED G9A INHIBITION AND HISTAMINE H3 RECEPTOR ANTAGONISM ENHANCES MEMORY AND ATTENUATES HIPPOCAMPAL OXIDATIVE STRESS IN BTBR MICE |
| 12:40 | Katarzyna Popiołek-Barczyk: PITOLISANT, A HISTAMINE H3 RECEPTOR ANTAGONIST/INVERSE AGONIST, REDUCES PAIN HYPERSENSITIVITY AND ALTERS MORPHINE ANALGESIA, ANXIETY-LIKE BEHAVIOUR AND METABOLISM IN A SEX-DEPENDENT MANNER IN A MURINE MODEL OF NEUROPATHIC PAIN |
| 13:00 | Mariusz Geremek: EFFECT OF HISTAMINE H3 RECEPTOR ANTAGONIST/INVERSE AGONIST DL76 ON HISTOPATHOLOGICAL AND MATRIX METALLOPROTEINASE-2 AND -9 EXPRESSION CHANGES IN EXPERIMENTAL PERIODONTITIS IN RATS (20min) |
| 13:00–15:00 | LUNCHTIME Lunch served in hotel restaurant |
| 15:00–16:40 | Session V. Future drugs Chairs: Rob Leurs & Dariusz Matosiuk |
| 15:00 | Holger Stark: Novel Modafinil Derivatives to Fight Narcolepsy |
| 15:30 | Mihajlo Gajić: RATIONAL DESIGN OF DUAL H3R/G9a LIGANDS FOR PRADER-WILLI SYNDROME RESEARCH |
| 15:50 | Katarzyna Szczepanska: TOWARDS MULTI-TARGET LIGANDS FOR PAIN THERAPY: DESIGN AND BIOLOGICAL EVALUATION OF COMPOUNDS DIRECTED AT SIGMA-1, HISTAMINE H3, AND µ-OPIOID RECEPTORS |
| 16:30 | VISITING ŁÓDŹ |
| 19:00 or 20:00 | GALA DINNER Gala dinner at the venue restaurant |
Saturday, 24 October 2026
| Time | Programme |
|---|---|
| 09:00–10:30 | HRSE General Assembly |
| 10:00–11:00 | PTBH General Assembly |
| 11:00–11:15 | COFFEE |
| 11:15–13:05 | Session VI. New Methodologies in Histamine Research Chairs: Joao Fernandes & Aleksandra Zivkovic |
| 11:15 | Katarzyna Koprowska: NEW METHODS OF LABELING BIOLOGICALLY ACTIVE COMPOUNDS WITH FLUORESCENT AND METALLOCARBONYL TAGS (20 min) |
| 11:35 | Rob Leurs: Photopharmacology of G Protein-Coupled Receptors: prospects and pitfalls within the histamine receptor family |
| 12:05 | Piotr Wojdasiewicz: CONCENTRATION- AND ENDPOINT-DEPENDENT RESPONSES OF PRIMARY HUMAN OSTEOBLASTS TO ROSAVIN, A CHARACTERISTIC CONSTITUENT OF RHODIOLA ROSEA |
| 12:25 | Piotr Mrówka: FROM ONCOGENIC SIGNALING TO CELLULAR CHEMISTRY: RAMAN READOUTS OF FLT3 INHIBITION IN ACUTE MYELOID LEUKEMIA |
| 12:45 | Edyta Wróbel: |
| 13:05 | CLOSING REMARKS Presentation of winners of competition for the best presentation & bursaries |
| 14:00 | LUNCH |
| Afternoon / evening | CULTURAL EVENT For attendees leaving on Sunday & Monday Dinner at the venue restaurant |
Please note that there may be some changes to the programme.
About the Meeting
Founded in Łódź in 1971 as the Histamine Club, the European organisation has evolved into the Histamine Research Society Europe (HRSE), reflecting the dynamic development of research on histamine and related biologically active compounds.
This joint conference marks the 52nd gathering of European histaminologists and the 20th biennial meeting of the Polish Society for Histamine Research, continuing a long-standing tradition of interdisciplinary collaboration.
Since the first meeting in Paris in 1972, the Society has held 51 scientific meetings, demonstrating its sustained commitment to advancing research in the field of histamine and biogenic amines.
📌 Venue:
Ambasador Centrum Hotel
Al. Marsz. Piłsudskiego 29, 90-307 Łódź, Poland
📅 Programme: 22–24 October 2026
Thursday (22 October) – from noon
Saturday (24 October) – until afternoon
🎵 Cultural Events:
Selected cultural and social events will
accompany the scientific programme
✈️Travel and Accessibility
Łódź is easily accessible by train, car, or airplane.
The city is served by a local airport, with additional
international connections available via Warsaw.
Conference Patrons
Don’t miss your chance!
The deadline for registration and abstract submission has been extended to
July 26, 2026.
Participation and Abstract Submission
We warmly invite you to participate in the meeting and submit your contribution using the abstract template.
KEYNOTE SPEAKERS
Phillippe De Deurwaerdère
(University of Bordeaux, France)
LECTURE
THE PSYCHEDELIC 5-METHOXY-DIMETHYLTRYPTAMINE (5-MeO-DMT) COUNTERACTS BEHAVIORAL CONSEQUENCES OF CHRONIC RESTRAINED STRESS WHILE INDUCING DISTINCT BRAIN ORGANIZATION OF NEUROTRANSMISSION SYSTEMS
Magdalena Kurnik-Łucka
(Jagiellonian University Cracow, Poland)
LECTURE
DOPAMINE IN THE GUT
Xavier Ligneau
(Bioprojet Biotech, France)
LECTURE
BP1.7881A, THE FIRST DUAL HISTAMINE H1-H4 RECEPTOR ANTAGONIST:
FROM PRECLINIC TO CLINICAL PHASE 2 STUDIES
Pertti Panula
(University of Helsinki, Finland)
LECTURE
DEVELOPMENTAL ROLES OF DOPAMINE IN THE EARLY BRAIN AND REGENERATION
Maria Beatrice Passani
(University of Florence, Italy)
LECTURE
THE DIVERSE ROLES OF HISTAMINE IN MODULATING COGNITIVE FUNCTIONS AND MAINTAINING INTERNAL BALANCE
Holger STARK
(Heinrich Heine University Düsseldorf, Germany)
LECTURE
NOVEL MODAFINIL DERIVATIVES TO FIGHT NARCOLEPSY
Katarzyna SZCZEPAŃSKA
(Maj Institute of Pharmacology Polish Academy of Sciences, Krakow, Poland)
LECTURE
TOWARDS MULTI-TARGET LIGANDS FOR PAIN THERAPY: DESIGN AND BIOLOGICAL EVALUATION OF COMPOUNDS DIRECTED AT SIGMA-1, HISTAMINE H3, AND Μ-OPIOID RECEPTORS
Dariusz Szukiewicz
(Warsaw Medical University, Poland)
LECTURE
HOW THE BRAIN’S HISTAMINE SYSTEM INFLUENCES NEURODEVELOPMENTAL AND NEURODEGENERATIVE DISORDERS
Satoshi TANAKA
(Kyoto Pharmaceutical University, Japan)
LECTURE
FUNCTIONAL ROLES OF MAS-RELATED G PROTEIN-COUPLED RECEPTOR FAMILY IN SCRATCHING
Henry F. VISCHER
(Vrije Universiteit Amsterdam, The Netherlands)
LECTURE
ENLIGHTNING H4R PHARMACOLOGY USING A FLUORESCENCE-BASED CONFORMATIONAL BIOSENSOR
Nicholas I. Carruthers
(NDC Medchem Consulting LLC, California, U.S.A)
LECTURE
HISTAMINE H3 ANTAGONISTS – PAST AND FUTURE
Call for Applications: International Bursary Grants for Early Stage Researchers to Support Participation in Joint Conference of HRSE and PTBH in Lodz, 2026
Bursary Call_ Lodz2026.pdf
Call for Applications: International Bursary Grants for Early Stage Researchers to Support Participation in Joint Conference of HRSE and PTBH in Lodz, 2026
Bursary Call_ Lodz2026.pdf
The Scientific and Organising Committee
Wieslawa Agnieszka FOGEL
Jerzy JOCHEM
Magdalena KURNIK
Rob LEURS
Detlef NEUMANN
Mariusz ROBOWSKI
Barbara SKRZYDŁO-RADOMANSKA
Holger STARK
Dariusz SZUKIEWICZ
Behind us…
19th English-speaking Conference of the Polish Histamine Research Society
“Biogenic Amines and Related Biologically Active Compounds”
Our distinguished guests, world-famous experts in the above-mentioned issues,
presented the latest scientific achievements in almost all fields of biomedical sciences.
Among them:
Enzo AGOSTINELLI (University La Sapienza, Rome, Italy),
Philippe DE DEURWAERDÈRE (CNRS, Bordeaux, France),
Jarosław DZIADEK (Institute of Medical Biology PAN, Łódź, Poland),
Madeleine ENNIS (QUB, Belfast, United Kingdom),
Beatrice PASSANI (Università degli Studi di Firenze, Florence, Italy),
Pertti PANULA (University of Helsinki, Helsinki, Finland),
Andrzej PILC (Maj Institute of Pharmacology PAS, Kraków, Poland),
Holger STARK (Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany).
Honorary Patrons of XIX Conference:
HRSE Histamine Research Society Europe
PTF Polish Physiological Society
PTG-E Polish Society of Gastroenterology
PTN Polish Neurological Society
Rector of Medical University of Lodz
President of the City of Lodz
Financial support of SolBet is acknowledged.
